Carmen Monton resigned as Spain's health minister after alleged irregularities in her academic record came to light.

"I have committed no irregularity, I insist on that and will continue to do so with total conviction and with a clear conscience," Monton told reporters at a press conference to announce her resignation, while asserting that she was "proud and thankful that Prime Minister Pedro Sanchez has counted on me for his government team."

Monton, who has now been replaced as health minister by the former high commissioner for the fight against childhood poverty, Maria Luisa Carcedo, found herself forced to provide explanations about a master's degree from Madrid's King Juan Carlos University after the online daily eldiario.es reported alleged misrepresentations in her academic record.

"All I can say as prime minister is that the minister is doing outstanding work and she's going to keep doing it," Sanchez told reporters earlier Tuesday.

The explicit support of Sanchez came after a day in which calls increased for the minister's resignation, even from inside the governing Socialist Party, after the university said it detected unexplained changes to Monton's academic transcript.

Early this morning Monton said on the radio that having to resign was "not fair" because it wasn't her fault if her grades were altered after she finished the course.

In announcing that she had presented her resignation to Sanchez, Monton said she has been "transparent and honest" and that she was resigning so her plight would not affect the government in any way.

Monton is the second member of Sanchez's Cabinet to resign since the administration took office June 1, after Maxim Huerta stepped down as minister of culture and sports when it was learned that he owed 218,000 euros ($252,783) in back taxes.