Porto's goalkeeper Iker Casillas is seeking to turn the tables in Wednesday's game against Liverpool after a 2-0 defeat to the English side in the Champions League.
After its Primeira Liga 3-0 win over Portimonense on Saturday, Porto was given the chance to compete against Benfica for first place in the table, with only five games left.
Porto's head coach Sergio Conceicao, did not rotate players in Saturday's game, in which forwards Yacine Brahimi, Moussa Marega and midfielder Hector Herrera scored three goals.
The 44-year-old Portuguese coach will not be able to count on forward Vincent Aboubakar, who has been injured since September with a cruciate ligament rupture.
Jesus Corona's participation is doubtful after the Mexican winger suffered a slight ankle sprain.
Conceicao restored two key players, defender Pepe and Herrera, who had both missed the first leg clash against Liverpool over a yellow-card-accumulation suspension.
Pepe's return is expected to put defender Eder Militao back on the righthand side, although another option is that Conceicao forms a pair of center-backs with the former Real Madrid player, while defender Maxi Pereira is set to play as a full-back on the right.
Herrera's comeback will mean midfielder Oliver Torres, who played in the first leg, will start the game on the bench.
Liverpool will face Porto after a 2-0 Premier League victory over Chelsea on Sunday, which means they lead the table with a two-point difference ahead of Manchester City.
Liverpool, which scored the most goals in the Premier League, knows that Porto has nothing to lose.
Porto: Casillas; Militao, Pepe, Felipe, Alex Telles, Otavio, Herrera, Danilo Pereira, Corona, Marega and Francisco Soares.
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson, Keita, Wijnaldum, Milner, Salah, Mane and Firmino. EFE